The Role of Monocarboxylate Transporters and Their Chaperone CD147 in Lactate Efflux Inhibition and the Anticancer Effects of Terminalia chebula in Neuroblastoma Cell Line N2-A
Identifieur interne : 000032 ( Main/Exploration ); précédent : 000031; suivant : 000033The Role of Monocarboxylate Transporters and Their Chaperone CD147 in Lactate Efflux Inhibition and the Anticancer Effects of Terminalia chebula in Neuroblastoma Cell Line N2-A
Auteurs : S. S. Messeha [États-Unis] ; N. O. Zarmouh [États-Unis] ; E. Taka [États-Unis] ; S. G. Gendy [États-Unis] ; G. R. Shokry [États-Unis] ; M. G. Kolta [États-Unis] ; K. F. A. Soliman [États-Unis]Source :
- European journal of medicinal plants [ 2231-0894 ] ; 2016.
Abstract
In the presence of oxygen, most of the synthesized pyruvate during glycolysis in the cancer cell of solid tumors is released away from the mitochondria to form lactate (Warburg Effect). To maintain cell homeostasis, lactate is transported across the cell membrane by monocarboxylate transporters (MCTs). The major aim of the current investigation is to identify novel compounds that inhibit lactate efflux that may lead to identifying effective targets for cancer treatment.
In this study, 900 ethanol plant extracts were screened for their lactate efflux inhibition using neuroblastoma (N2-A) cell line. Additionally, we investigated the mechanism of inhibition for the most potent plant extract regarding monocarboxylate transporters expression, and consequences effects on viability, growth, and apoptosis.
The potency of lactate efflux inhibition of ethanol plant extracts was evaluated in N2-A cells by measuring extracellular lactate levels. Caspase 3- activity and acridine orange/ethidium bromide staining were performed to assess the apoptotic effect. The antiproliferative effect was measured using WST assay. Western blotting was performed to quantify protein expression of MCTs and their chaperone CD147 in treated cells lysates.
Out of the 900 plant extracts screened,
Url:
DOI: 10.9734/EJMP/2016/23992
PubMed: 27158628
PubMed Central: 4857771
Affiliations:
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S." last="Messeha">S. S. Messeha</name><affiliation wicri:level="1"><nlm:aff id="A1">College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307</wicri:regionArea><wicri:noRegion>Florida 32307</wicri:noRegion></affiliation></author><author><name sortKey="Zarmouh, N O" sort="Zarmouh, N O" uniqKey="Zarmouh N" first="N. O." last="Zarmouh">N. O. Zarmouh</name><affiliation wicri:level="1"><nlm:aff id="A1">College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307</wicri:regionArea><wicri:noRegion>Florida 32307</wicri:noRegion></affiliation></author><author><name sortKey="Taka, E" sort="Taka, E" uniqKey="Taka E" first="E." last="Taka">E. Taka</name><affiliation wicri:level="1"><nlm:aff id="A1">College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307</wicri:regionArea><wicri:noRegion>Florida 32307</wicri:noRegion></affiliation></author><author><name sortKey="Gendy, S G" sort="Gendy, S G" uniqKey="Gendy S" first="S. G." last="Gendy">S. G. Gendy</name><affiliation wicri:level="1"><nlm:aff id="A1">College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307</wicri:regionArea><wicri:noRegion>Florida 32307</wicri:noRegion></affiliation></author><author><name sortKey="Shokry, G R" sort="Shokry, G R" uniqKey="Shokry G" first="G. R." last="Shokry">G. R. Shokry</name><affiliation wicri:level="1"><nlm:aff id="A1">College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307</wicri:regionArea><wicri:noRegion>Florida 32307</wicri:noRegion></affiliation></author><author><name sortKey="Kolta, M G" sort="Kolta, M G" uniqKey="Kolta M" first="M. G." last="Kolta">M. G. Kolta</name><affiliation wicri:level="1"><nlm:aff id="A1">College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307</wicri:regionArea><wicri:noRegion>Florida 32307</wicri:noRegion></affiliation></author><author><name sortKey="Soliman, K F A" sort="Soliman, K F A" uniqKey="Soliman K" first="K. F. A." last="Soliman">K. F. A. Soliman</name><affiliation wicri:level="1"><nlm:aff id="A1">College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307</wicri:regionArea><wicri:noRegion>Florida 32307</wicri:noRegion></affiliation></author></analytic><series><title level="j">European journal of medicinal plants</title><idno type="eISSN">2231-0894</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Aims</title><p id="P1">In the presence of oxygen, most of the synthesized pyruvate during glycolysis in the cancer cell of solid tumors is released away from the mitochondria to form lactate (Warburg Effect). To maintain cell homeostasis, lactate is transported across the cell membrane by monocarboxylate transporters (MCTs). The major aim of the current investigation is to identify novel compounds that inhibit lactate efflux that may lead to identifying effective targets for cancer treatment.</p></sec><sec id="S2"><title>Study Design</title><p id="P2">In this study, 900 ethanol plant extracts were screened for their lactate efflux inhibition using neuroblastoma (N2-A) cell line. Additionally, we investigated the mechanism of inhibition for the most potent plant extract regarding monocarboxylate transporters expression, and consequences effects on viability, growth, and apoptosis.</p></sec><sec id="S3"><title>Methodology</title><p id="P3">The potency of lactate efflux inhibition of ethanol plant extracts was evaluated in N2-A cells by measuring extracellular lactate levels. Caspase 3- activity and acridine orange/ethidium bromide staining were performed to assess the apoptotic effect. The antiproliferative effect was measured using WST assay. Western blotting was performed to quantify protein expression of MCTs and their chaperone CD147 in treated cells lysates.</p></sec><sec id="S4"><title>Results</title><p id="P4"><italic>Terminalia chebula</italic> plant extract was the most potent lactate efflux inhibitor in N2-A cells among the 900 - tested plant extracts. The results obtained show that extract of <italic>Terminalia chebula</italic> fruits (<bold>TCE</bold>) significantly (<italic>P</italic> = 0.05) reduced the expression of the MCT1, MCT3, MCT4 and the chaperone CD147. The plant extract was more potent (IC<sub>50</sub> of 3.59 ± 0.26 μg/ml) than the MCT standard inhibitor phloretin (IC<sub>50</sub> 76.54 ± 3.19 μg/ml). The extract also showed more potency and selective cytotoxicity in cancer cells than DI-TNC1 primary cell line (IC<sub>50</sub> 7.37 ± 0.28 vs. 17.35 ± 0.19 μg/ml). Moreover, <bold>TCE</bold> Inhibited N2-A cell growth (IG<sub>50</sub> = 5.20 ± 0.30 μg/ml) and induced apoptosis at the 7.5 μg/ml concentration.</p></sec><sec id="S5"><title>Conclusion</title><p id="P5">Out of the 900 plant extracts screened, <italic>Terminalia chebula</italic> ethanol extract was found to be the most potent lactate efflux inhibitor with the ability to inhibit chaperone CD147 expression and impact the function of monocarboxylate transporters. Furthermore, TCE was found to have growth inhibition and apoptotic effects. The results obtained indicate that <italic>Terminalia chebula</italic> constituent(s) may contain promising compounds that can be useful in the management of neuroblastoma cancer.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Warburg, O" uniqKey="Warburg O">O Warburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Draoui, N" uniqKey="Draoui N">N Draoui</name></author><author><name sortKey="Feron, O" uniqKey="Feron O">O Feron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitaker Menezes, D" uniqKey="Whitaker Menezes D">D Whitaker-Menezes</name></author><author><name sortKey="Martinez Outschoorn, Ue" uniqKey="Martinez Outschoorn U">UE Martinez-Outschoorn</name></author><author><name sortKey="Lin, Z" uniqKey="Lin Z">Z Lin</name></author><author><name sortKey="Ertel, A" uniqKey="Ertel A">A Ertel</name></author><author><name sortKey="Flomenberg, N" uniqKey="Flomenberg N">N Flomenberg</name></author><author><name sortKey="Witkiewicz, Ak" uniqKey="Witkiewicz A">AK Witkiewicz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez Zaguilan, R" uniqKey="Martinez Zaguilan R">R Martinez-Zaguilan</name></author><author><name sortKey="Seftor, Ea" uniqKey="Seftor E">EA Seftor</name></author><author><name sortKey="Seftor, Re" uniqKey="Seftor R">RE Seftor</name></author><author><name sortKey="Chu, Yw" uniqKey="Chu Y">YW Chu</name></author><author><name sortKey="Gillies, Rj" uniqKey="Gillies R">RJ Gillies</name></author><author><name sortKey="Hendrix, Mj" uniqKey="Hendrix M">MJ Hendrix</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schlappack, Ok" uniqKey="Schlappack O">OK Schlappack</name></author><author><name sortKey="Zimmermann, A" uniqKey="Zimmermann A">A Zimmermann</name></author><author><name sortKey="Hill, Rp" uniqKey="Hill R">RP Hill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tredan, O" uniqKey="Tredan O">O Tredan</name></author><author><name sortKey="Galmarini, Cm" uniqKey="Galmarini C">CM Galmarini</name></author><author><name sortKey="Patel, K" uniqKey="Patel K">K Patel</name></author><author><name sortKey="Tannock, If" uniqKey="Tannock I">IF Tannock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Izumi, H" uniqKey="Izumi H">H Izumi</name></author><author><name sortKey="Takahashi, M" uniqKey="Takahashi M">M Takahashi</name></author><author><name sortKey="Uramoto, H" uniqKey="Uramoto H">H Uramoto</name></author><author><name sortKey="Nakayama, Y" uniqKey="Nakayama Y">Y Nakayama</name></author><author><name sortKey="Oyama, T" uniqKey="Oyama T">T Oyama</name></author><author><name sortKey="Wang, Ky" uniqKey="Wang K">KY Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thammasit, P" uniqKey="Thammasit P">P Thammasit</name></author><author><name sortKey="Sangboonruang, S" uniqKey="Sangboonruang S">S Sangboonruang</name></author><author><name sortKey="Suwanpairoj, S" uniqKey="Suwanpairoj S">S Suwanpairoj</name></author><author><name sortKey="Khamaikawin, W" uniqKey="Khamaikawin W">W Khamaikawin</name></author><author><name sortKey="Intasai, N" uniqKey="Intasai N">N Intasai</name></author><author><name sortKey="Kasinrerk, W" uniqKey="Kasinrerk W">W Kasinrerk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsuyama, S" uniqKey="Matsuyama S">S Matsuyama</name></author><author><name sortKey="Llopis, J" uniqKey="Llopis J">J Llopis</name></author><author><name sortKey="Deveraux, Ql" uniqKey="Deveraux Q">QL Deveraux</name></author><author><name sortKey="Tsien, Ry" uniqKey="Tsien R">RY Tsien</name></author><author><name sortKey="Reed, Jc" uniqKey="Reed J">JC Reed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barry, Ma" uniqKey="Barry M">MA Barry</name></author><author><name sortKey="Eastman, A" uniqKey="Eastman A">A Eastman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Hj" uniqKey="Park H">HJ Park</name></author><author><name sortKey="Lyons, Jc" uniqKey="Lyons J">JC Lyons</name></author><author><name sortKey="Ohtsubo, T" uniqKey="Ohtsubo T">T Ohtsubo</name></author><author><name sortKey="Song, Cw" uniqKey="Song C">CW Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grinstein, S" uniqKey="Grinstein S">S Grinstein</name></author><author><name sortKey="Rotin, D" uniqKey="Rotin D">D Rotin</name></author><author><name sortKey="Mason, Mj" uniqKey="Mason M">MJ Mason</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillies, Rj" uniqKey="Gillies R">RJ Gillies</name></author><author><name sortKey="Martinez Zaguilan, R" uniqKey="Martinez Zaguilan R">R Martinez-Zaguilan</name></author><author><name sortKey="Martinez, Gm" uniqKey="Martinez G">GM Martinez</name></author><author><name sortKey="Serrano, R" uniqKey="Serrano R">R Serrano</name></author><author><name sortKey="Perona, R" uniqKey="Perona R">R Perona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halestrap, Ap" uniqKey="Halestrap A">AP Halestrap</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sonveaux, P" uniqKey="Sonveaux P">P Sonveaux</name></author><author><name sortKey="Vegran, F" uniqKey="Vegran F">F Vegran</name></author><author><name sortKey="Schroeder, T" uniqKey="Schroeder T">T Schroeder</name></author><author><name sortKey="Wergin, Mc" uniqKey="Wergin M">MC Wergin</name></author><author><name sortKey="Verrax, J" uniqKey="Verrax J">J Verrax</name></author><author><name sortKey="Rabbani, Zn" uniqKey="Rabbani Z">ZN Rabbani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halestrap, Ap" uniqKey="Halestrap A">AP Halestrap</name></author><author><name sortKey="Price, Nt" uniqKey="Price N">NT Price</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pinheiro, C" uniqKey="Pinheiro C">C Pinheiro</name></author><author><name sortKey="Longatto Filho, A" uniqKey="Longatto Filho A">A Longatto-Filho</name></author><author><name sortKey="Azevedo Silva, J" uniqKey="Azevedo Silva J">J Azevedo-Silva</name></author><author><name sortKey="Casal, M" uniqKey="Casal M">M Casal</name></author><author><name sortKey="Schmitt, Fc" uniqKey="Schmitt F">FC Schmitt</name></author><author><name sortKey="Baltazar, F" uniqKey="Baltazar F">F Baltazar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sankara Aditya, J" uniqKey="Sankara Aditya J">J Sankara Aditya</name></author><author><name sortKey="Kumar, L Naresh" uniqKey="Kumar L">L. Naresh Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shim, Ck" uniqKey="Shim C">CK Shim</name></author><author><name sortKey="Cheon, Ep" uniqKey="Cheon E">EP Cheon</name></author><author><name sortKey="Kang, Kw" uniqKey="Kang K">KW Kang</name></author><author><name sortKey="Seo, Ks" uniqKey="Seo K">KS Seo</name></author><author><name sortKey="Han, Hk" uniqKey="Han H">HK Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baltazar, F" uniqKey="Baltazar F">F Baltazar</name></author><author><name sortKey="Pinheiro, C" uniqKey="Pinheiro C">C Pinheiro</name></author><author><name sortKey="Morais Santos, F" uniqKey="Morais Santos F">F Morais-Santos</name></author><author><name sortKey="Azevedo Silva, J" uniqKey="Azevedo Silva J">J Azevedo-Silva</name></author><author><name sortKey="Queiros, O" uniqKey="Queiros O">O Queiros</name></author><author><name sortKey="Preto, A" uniqKey="Preto A">A Preto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cieniak, C" uniqKey="Cieniak C">C Cieniak</name></author><author><name sortKey="Walshe Roussel, B" uniqKey="Walshe Roussel B">B Walshe-Roussel</name></author><author><name sortKey="Liu, R" uniqKey="Liu R">R Liu</name></author><author><name sortKey="Muhammad, A" uniqKey="Muhammad A">A Muhammad</name></author><author><name sortKey="Saleem, A" uniqKey="Saleem A">A Saleem</name></author><author><name sortKey="Haddad, Ps" uniqKey="Haddad P">PS Haddad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mazzio, Ea" uniqKey="Mazzio E">EA Mazzio</name></author><author><name sortKey="Soliman, Kf" uniqKey="Soliman K">KF Soliman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finklestein, Jz" uniqKey="Finklestein J">JZ Finklestein</name></author><author><name sortKey="Tittle, K" uniqKey="Tittle K">K Tittle</name></author><author><name sortKey="Meshnik, R" uniqKey="Meshnik R">R Meshnik</name></author><author><name sortKey="Weiner, J" uniqKey="Weiner J">J Weiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mazzio, Ea" uniqKey="Mazzio E">EA Mazzio</name></author><author><name sortKey="Boukli, N" uniqKey="Boukli N">N Boukli</name></author><author><name sortKey="Rivera, N" uniqKey="Rivera N">N Rivera</name></author><author><name sortKey="Soliman, Kf" uniqKey="Soliman K">KF Soliman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mazzio, Ea" uniqKey="Mazzio E">EA Mazzio</name></author><author><name sortKey="Smith, B" uniqKey="Smith B">B Smith</name></author><author><name sortKey="Soliman, Kf" uniqKey="Soliman K">KF Soliman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mazzio, E" uniqKey="Mazzio E">E Mazzio</name></author><author><name sortKey="Soliman, Kf" uniqKey="Soliman K">KF Soliman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Magistretti, Pj" uniqKey="Magistretti P">PJ Magistretti</name></author><author><name sortKey="Pellerin, L" uniqKey="Pellerin L">L Pellerin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pellerin, L" uniqKey="Pellerin L">L Pellerin</name></author><author><name sortKey="Stolz, M" uniqKey="Stolz M">M Stolz</name></author><author><name sortKey="Sorg, O" uniqKey="Sorg O">O Sorg</name></author><author><name sortKey="Martin, Jl" uniqKey="Martin J">JL Martin</name></author><author><name sortKey="Deschepper, Cf" uniqKey="Deschepper C">CF Deschepper</name></author><author><name sortKey="Magistretti, Pj" uniqKey="Magistretti P">PJ Magistretti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fang, J" uniqKey="Fang J">J Fang</name></author><author><name sortKey="Quinones, Qj" uniqKey="Quinones Q">QJ Quinones</name></author><author><name sortKey="Holman, Tl" uniqKey="Holman T">TL Holman</name></author><author><name sortKey="Morowitz, Mj" uniqKey="Morowitz M">MJ Morowitz</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Zhao, H" uniqKey="Zhao H">H Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, Aa" uniqKey="Khan A">AA Khan</name></author><author><name sortKey="Kumar, V" uniqKey="Kumar V">V Kumar</name></author><author><name sortKey="Singh, Bk" uniqKey="Singh B">BK Singh</name></author><author><name sortKey="Singh, R" uniqKey="Singh R">R Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valsaraj, R" uniqKey="Valsaraj R">R Valsaraj</name></author><author><name sortKey="Pushpangadan, P" uniqKey="Pushpangadan P">P Pushpangadan</name></author><author><name sortKey="Smitt, Uw" uniqKey="Smitt U">UW Smitt</name></author><author><name sortKey="Adsersen, A" uniqKey="Adsersen A">A Adsersen</name></author><author><name sortKey="Christensen, Sb" uniqKey="Christensen S">SB Christensen</name></author><author><name sortKey="Sittie, A" uniqKey="Sittie A">A Sittie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bagavan, A" uniqKey="Bagavan A">A Bagavan</name></author><author><name sortKey="Rahuman, Aa" uniqKey="Rahuman A">AA Rahuman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nair, V" uniqKey="Nair V">V Nair</name></author><author><name sortKey="Singh, S" uniqKey="Singh S">S Singh</name></author><author><name sortKey="Gupta, Yk" uniqKey="Gupta Y">YK Gupta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Yn" uniqKey="Huang Y">YN Huang</name></author><author><name sortKey="Zhao, Dd" uniqKey="Zhao D">DD Zhao</name></author><author><name sortKey="Gao, B" uniqKey="Gao B">B Gao</name></author><author><name sortKey="Zhong, K" uniqKey="Zhong K">K Zhong</name></author><author><name sortKey="Zhu, Rx" uniqKey="Zhu R">RX Zhu</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Hs" uniqKey="Lee H">HS Lee</name></author><author><name sortKey="Jung, Sh" uniqKey="Jung S">SH Jung</name></author><author><name sortKey="Yun, Bs" uniqKey="Yun B">BS Yun</name></author><author><name sortKey="Lee, Kw" uniqKey="Lee K">KW Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Sun, F" uniqKey="Sun F">F Sun</name></author><author><name sortKey="Ma, L" uniqKey="Ma L">L Ma</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Qin, H" uniqKey="Qin H">H Qin</name></author><author><name sortKey="Du, G" uniqKey="Du G">G Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shin, Ty" uniqKey="Shin T">TY Shin</name></author><author><name sortKey="Jeong, Hj" uniqKey="Jeong H">HJ Jeong</name></author><author><name sortKey="Kim, Dk" uniqKey="Kim D">DK Kim</name></author><author><name sortKey="Kim, Sh" uniqKey="Kim S">SH Kim</name></author><author><name sortKey="Lee, Jk" uniqKey="Lee J">JK Lee</name></author><author><name sortKey="Kim, Dk" uniqKey="Kim D">DK Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaur, S" uniqKey="Kaur S">S Kaur</name></author><author><name sortKey="Grover, Is" uniqKey="Grover I">IS Grover</name></author><author><name sortKey="Singh, M" uniqKey="Singh M">M Singh</name></author><author><name sortKey="Kaur, S" uniqKey="Kaur S">S Kaur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saleem, A" uniqKey="Saleem A">A Saleem</name></author><author><name sortKey="Husheem, M" uniqKey="Husheem M">M Husheem</name></author><author><name sortKey="Harkonen, P" uniqKey="Harkonen P">P Harkonen</name></author><author><name sortKey="Pihlaja, K" uniqKey="Pihlaja K">K Pihlaja</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartwell, Jl" uniqKey="Hartwell J">JL Hartwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tagne, Rs" uniqKey="Tagne R">RS Tagne</name></author><author><name sortKey="Telefo, Bp" uniqKey="Telefo B">BP Telefo</name></author><author><name sortKey="Nyemb, Jn" uniqKey="Nyemb J">JN Nyemb</name></author><author><name sortKey="Yemele, Dm" uniqKey="Yemele D">DM Yemele</name></author><author><name sortKey="Njina, Sn" uniqKey="Njina S">SN Njina</name></author><author><name sortKey="Goka, Sm" uniqKey="Goka S">SM Goka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, N" uniqKey="Kumar N">N Kumar</name></author><author><name sortKey="Gangappa, D" uniqKey="Gangappa D">D Gangappa</name></author><author><name sortKey="Gupta, G" uniqKey="Gupta G">G Gupta</name></author><author><name sortKey="Karnati, R" uniqKey="Karnati R">R Karnati</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghate, Nb" uniqKey="Ghate N">NB Ghate</name></author><author><name sortKey="Hazra, B" uniqKey="Hazra B">B Hazra</name></author><author><name sortKey="Sarkar, R" uniqKey="Sarkar R">R Sarkar</name></author><author><name sortKey="Chaudhuri, D" uniqKey="Chaudhuri D">D Chaudhuri</name></author><author><name sortKey="Mandal, N" uniqKey="Mandal N">N Mandal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Mekkawy, S" uniqKey="El Mekkawy S">S el-Mekkawy</name></author><author><name sortKey="Meselhy, Mr" uniqKey="Meselhy M">MR Meselhy</name></author><author><name sortKey="Kusumoto, It" uniqKey="Kusumoto I">IT Kusumoto</name></author><author><name sortKey="Kadota, S" uniqKey="Kadota S">S Kadota</name></author><author><name sortKey="Hattori, M" uniqKey="Hattori M">M Hattori</name></author><author><name sortKey="Namba, T" uniqKey="Namba T">T Namba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belapurkar, P" uniqKey="Belapurkar P">P Belapurkar</name></author><author><name sortKey="Goyal, P" uniqKey="Goyal P">P Goyal</name></author><author><name sortKey="Tiwari Barua, P" uniqKey="Tiwari Barua P">P Tiwari-Barua</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gaire, Bp" uniqKey="Gaire B">BP Gaire</name></author><author><name sortKey="Kim, H" uniqKey="Kim H">H Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bag, A" uniqKey="Bag A">A Bag</name></author><author><name sortKey="Kumar Bhattacharyya, S" uniqKey="Kumar Bhattacharyya S">S Kumar Bhattacharyya</name></author><author><name sortKey="Kumar Pal, N" uniqKey="Kumar Pal N">N Kumar Pal</name></author><author><name sortKey="Ranjan Chattopadhyay, R" uniqKey="Ranjan Chattopadhyay R">R Ranjan Chattopadhyay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalaiselvan, S" uniqKey="Kalaiselvan S">S Kalaiselvan</name></author><author><name sortKey="Rasool, Mk" uniqKey="Rasool M">MK Rasool</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deep, G" uniqKey="Deep G">G Deep</name></author><author><name sortKey="Dhiman, M" uniqKey="Dhiman M">M Dhiman</name></author><author><name sortKey="Rao, Ar" uniqKey="Rao A">AR Rao</name></author><author><name sortKey="Kale, Rk" uniqKey="Kale R">RK Kale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Poole, Rc" uniqKey="Poole R">RC Poole</name></author><author><name sortKey="Halestrap, Ap" uniqKey="Halestrap A">AP Halestrap</name></author><author><name sortKey="Levi, Aj" uniqKey="Levi A">AJ Levi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colen, Cb" uniqKey="Colen C">CB Colen</name></author><author><name sortKey="Shen, Y" uniqKey="Shen Y">Y Shen</name></author><author><name sortKey="Ghoddoussi, F" uniqKey="Ghoddoussi F">F Ghoddoussi</name></author><author><name sortKey="Yu, P" uniqKey="Yu P">P Yu</name></author><author><name sortKey="Francis, Tb" uniqKey="Francis T">TB Francis</name></author><author><name sortKey="Koch, Bj" uniqKey="Koch B">BJ Koch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deuticke, B" uniqKey="Deuticke B">B Deuticke</name></author><author><name sortKey="Rickert, I" uniqKey="Rickert I">I Rickert</name></author><author><name sortKey="Beyer, E" uniqKey="Beyer E">E Beyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sonveaux, P" uniqKey="Sonveaux P">P Sonveaux</name></author><author><name sortKey="Copetti, T" uniqKey="Copetti T">T Copetti</name></author><author><name sortKey="De Saedeleer, Cj" uniqKey="De Saedeleer C">CJ De Saedeleer</name></author><author><name sortKey="Vegran, F" uniqKey="Vegran F">F Vegran</name></author><author><name sortKey="Verrax, J" uniqKey="Verrax J">J Verrax</name></author><author><name sortKey="Kennedy, Km" uniqKey="Kennedy K">KM Kennedy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volk, C" uniqKey="Volk C">C Volk</name></author><author><name sortKey="Kempski, B" uniqKey="Kempski B">B Kempski</name></author><author><name sortKey="Kempski, Os" uniqKey="Kempski O">OS Kempski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colen, Cb" uniqKey="Colen C">CB Colen</name></author><author><name sortKey="Seraji Bozorgzad, N" uniqKey="Seraji Bozorgzad N">N Seraji-Bozorgzad</name></author><author><name sortKey="Marples, B" uniqKey="Marples B">B Marples</name></author><author><name sortKey="Galloway, Mp" uniqKey="Galloway M">MP Galloway</name></author><author><name sortKey="Sloan, Ae" uniqKey="Sloan A">AE Sloan</name></author><author><name sortKey="Mathupala, Sp" uniqKey="Mathupala S">SP Mathupala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pellati, F" uniqKey="Pellati F">F Pellati</name></author><author><name sortKey="Bruni, R" uniqKey="Bruni R">R Bruni</name></author><author><name sortKey="Righi, D" uniqKey="Righi D">D Righi</name></author><author><name sortKey="Grandini, A" uniqKey="Grandini A">A Grandini</name></author><author><name sortKey="Tognolini, M" uniqKey="Tognolini M">M Tognolini</name></author><author><name sortKey="Pio Prencipe, F" uniqKey="Pio Prencipe F">F Pio Prencipe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sireeratawong, S" uniqKey="Sireeratawong S">S Sireeratawong</name></author><author><name sortKey="Jaijoy, K" uniqKey="Jaijoy K">K Jaijoy</name></author><author><name sortKey="Panunto, W" uniqKey="Panunto W">W Panunto</name></author><author><name sortKey="Nanna, U" uniqKey="Nanna U">U Nanna</name></author><author><name sortKey="Lertprasertsuke, N" uniqKey="Lertprasertsuke N">N Lertprasertsuke</name></author><author><name sortKey="Soonthornchareonnon, N" uniqKey="Soonthornchareonnon N">N Soonthornchareonnon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindinger, Mi" uniqKey="Lindinger M">MI Lindinger</name></author><author><name sortKey="Leung, Mj" uniqKey="Leung M">MJ Leung</name></author><author><name sortKey="Hawke, Tj" uniqKey="Hawke T">TJ Hawke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moley, Kh" uniqKey="Moley K">KH Moley</name></author><author><name sortKey="Mueckler, Mm" uniqKey="Mueckler M">MM Mueckler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pinheiro, C" uniqKey="Pinheiro C">C Pinheiro</name></author><author><name sortKey="Longatto Filho, A" uniqKey="Longatto Filho A">A Longatto-Filho</name></author><author><name sortKey="Scapulatempo, C" uniqKey="Scapulatempo C">C Scapulatempo</name></author><author><name sortKey="Ferreira, L" uniqKey="Ferreira L">L Ferreira</name></author><author><name sortKey="Martins, S" uniqKey="Martins S">S Martins</name></author><author><name sortKey="Pellerin, L" uniqKey="Pellerin L">L Pellerin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Broer, S" uniqKey="Broer S">S Broer</name></author><author><name sortKey="Broer, A" uniqKey="Broer A">A Broer</name></author><author><name sortKey="Schneider, Hp" uniqKey="Schneider H">HP Schneider</name></author><author><name sortKey="Stegen, C" uniqKey="Stegen C">C Stegen</name></author><author><name sortKey="Halestrap, Ap" uniqKey="Halestrap A">AP Halestrap</name></author><author><name sortKey="Deitmer, Jw" uniqKey="Deitmer J">JW Deitmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marchiq, I" uniqKey="Marchiq I">I Marchiq</name></author><author><name sortKey="Albrengues, J" uniqKey="Albrengues J">J Albrengues</name></author><author><name sortKey="Granja, S" uniqKey="Granja S">S Granja</name></author><author><name sortKey="Gaggioli, C" uniqKey="Gaggioli C">C Gaggioli</name></author><author><name sortKey="Pouyssegur, J" uniqKey="Pouyssegur J">J Pouyssegur</name></author><author><name sortKey="Simon, Mp" uniqKey="Simon M">MP Simon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kirk, P" uniqKey="Kirk P">P Kirk</name></author><author><name sortKey="Wilson, Mc" uniqKey="Wilson M">MC Wilson</name></author><author><name sortKey="Heddle, C" uniqKey="Heddle C">C Heddle</name></author><author><name sortKey="Brown, Mh" uniqKey="Brown M">MH Brown</name></author><author><name sortKey="Barclay, An" uniqKey="Barclay A">AN Barclay</name></author><author><name sortKey="Halestrap, Ap" uniqKey="Halestrap A">AP Halestrap</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hussien, R" uniqKey="Hussien R">R Hussien</name></author><author><name sortKey="Brooks, Ga" uniqKey="Brooks G">GA Brooks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fiaschi, T" uniqKey="Fiaschi T">T Fiaschi</name></author><author><name sortKey="Marini, A" uniqKey="Marini A">A Marini</name></author><author><name sortKey="Giannoni, E" uniqKey="Giannoni E">E Giannoni</name></author><author><name sortKey="Taddei, Ml" uniqKey="Taddei M">ML Taddei</name></author><author><name sortKey="Gandellini, P" uniqKey="Gandellini P">P Gandellini</name></author><author><name sortKey="De Donatis, A" uniqKey="De Donatis A">A De Donatis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zimmermann, Kc" uniqKey="Zimmermann K">KC Zimmermann</name></author><author><name sortKey="Green, Dr" uniqKey="Green D">DR Green</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sugantha Priya, E" uniqKey="Sugantha Priya E">E Sugantha Priya</name></author><author><name sortKey="Selvakumar, K" uniqKey="Selvakumar K">K Selvakumar</name></author><author><name sortKey="Bavithra, S" uniqKey="Bavithra S">S Bavithra</name></author><author><name sortKey="Elumalai, P" uniqKey="Elumalai P">P Elumalai</name></author><author><name sortKey="Arunkumar, R" uniqKey="Arunkumar R">R Arunkumar</name></author><author><name sortKey="Raja Singh, P" uniqKey="Raja Singh P">P Raja Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reddy, Db" uniqKey="Reddy D">DB Reddy</name></author><author><name sortKey="Reddy, Tc" uniqKey="Reddy T">TC Reddy</name></author><author><name sortKey="Jyotsna, G" uniqKey="Jyotsna G">G Jyotsna</name></author><author><name sortKey="Sharan, S" uniqKey="Sharan S">S Sharan</name></author><author><name sortKey="Priya, N" uniqKey="Priya N">N Priya</name></author><author><name sortKey="Lakshmipathi, V" uniqKey="Lakshmipathi V">V Lakshmipathi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Lee, Sy" uniqKey="Lee S">SY Lee</name></author><author><name sortKey="Lin, Cl" uniqKey="Lin C">CL Lin</name></author><author><name sortKey="Tu, Th" uniqKey="Tu T">TH Tu</name></author><author><name sortKey="Chen, Lh" uniqKey="Chen L">LH Chen</name></author><author><name sortKey="Chen, Yj" uniqKey="Chen Y">YJ Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Lg" uniqKey="Chen L">LG Chen</name></author><author><name sortKey="Huang, Wt" uniqKey="Huang W">WT Huang</name></author><author><name sortKey="Lee, Lt" uniqKey="Lee L">LT Lee</name></author><author><name sortKey="Wang, Cc" uniqKey="Wang C">CC Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morais Santos, F" uniqKey="Morais Santos F">F Morais-Santos</name></author><author><name sortKey="Miranda Goncalves, V" uniqKey="Miranda Goncalves V">V Miranda-Gonçalves</name></author><author><name sortKey="Pinheiro, S" uniqKey="Pinheiro S">S Pinheiro</name></author><author><name sortKey="Vieira, Af" uniqKey="Vieira A">AF Vieira</name></author><author><name sortKey="Paredes, J" uniqKey="Paredes J">J Paredes</name></author><author><name sortKey="Schmitt, Fc" uniqKey="Schmitt F">FC Schmitt</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Messeha, S S" sort="Messeha, S S" uniqKey="Messeha S" first="S. S." last="Messeha">S. S. Messeha</name></noRegion><name sortKey="Gendy, S G" sort="Gendy, S G" uniqKey="Gendy S" first="S. G." last="Gendy">S. G. Gendy</name><name sortKey="Kolta, M G" sort="Kolta, M G" uniqKey="Kolta M" first="M. G." last="Kolta">M. G. Kolta</name><name sortKey="Shokry, G R" sort="Shokry, G R" uniqKey="Shokry G" first="G. R." last="Shokry">G. R. Shokry</name><name sortKey="Soliman, K F A" sort="Soliman, K F A" uniqKey="Soliman K" first="K. F. A." last="Soliman">K. F. A. Soliman</name><name sortKey="Taka, E" sort="Taka, E" uniqKey="Taka E" first="E." last="Taka">E. Taka</name><name sortKey="Zarmouh, N O" sort="Zarmouh, N O" uniqKey="Zarmouh N" first="N. O." last="Zarmouh">N. O. Zarmouh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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